THE ENDECE APPROACH TO COVID-19
NDC-1308 (MC1) may reduce the number of SARS-CoV-2 positive individuals requiring hospitalization.
ENDECE developed NDC-1308 (MC1), a potential treatment for SARS-CoV-2, which has caused the current COVID-19 pandemic. NDC-1308 (MC1) has the potential to reduce lung inflammation by upregulating key genes that produce active Lipoprotein Lipase (LPL) by targeting macrophages within the lungs. Increased levels of LPL directly polarizes these macrophages from the M1 state (pro-inflammatory, anti-repair), to the M2 state (anti-inflammatory, pro-repair). By reducing chronic lung inflammation, NDC-1308 (MC1) may reduce and even prevent time on ventilators.
COVID-19 AND YOUR LUNGS
SARS-CoV-2 is a virus that is easily spread, causing the current COVID-19 respiratory disease. Once infected, SARS-CoV-2 travels through the respiratory tract into the lungs where cytokines are released, attracting macrophages to the region and triggering an attack on the virus. This immune system response to SARS-CoV-2 causes the lungs and airways to become inflamed due to M1 macrophages (pro-inflammatory, anti-repair).
As the inflammation becomes worse, the lungs can fill with fluid and mucus, making it harder for the body to take in oxygen. This can lead to Acute Respiratory Distress Syndrome (ARDS). With COVID-19, patients placed on mechanical ventilators have an 88% mortality rate.
NDC-1308 (MC1) works at the gene level and produces active Lipoprotein Lipase (LPL), which polarize these M1 macrophages to the M2 state (anti-inflammatory, pro-repair). By reducing lung inflammation, NDC-1308 (MC1) is a therapeutic designed to minimize the acute severe respiratory response, and significantly reduce or even prevent time on ventilators while allowing the body’s natural immune system to fight the attacking virus.
FUTURE SARS-CoV OUTBREAKS
SARS-CoV-2 is not the first coronavirus and won’t be the last. However, there is one underlying condition that all SARS-CoV affects, and that is the pulmonary system. Once contracted, SARS-CoV follows the respiratory tract into the lungs, where chronic inflammation can cause Acute Respiratory Distress Syndrome (ARDS).
Because the NDC-1308 (MC1) approach is agnostic to the type of pulmonary infection, we should be able to treat lung inflammation regardless of future infections.