EXPERTS IN DRUG DISCOVERY AND DEVELOPMENT

ENDECE is focused on developing proprietary novel drugs that impact lung inflammation, neuroinflammation and neurodegeneration in chronic, debilitating, and life threatening diseases for which treatment options are limited or non-existent. Our library of proprietary compounds is designed to activate multiple genes within specific biological pathways to stop progression, repair damage, and restore function for people with diseases such as COVID-19 (SARS-CoV-2), Niemann-Pick disease type C (NPC1), Neuromyelitis Optica Spectrum Disorder (NMOSD), Multiple Sclerosis (MS), Alzheimer’s Disease (AD), and Osmotic Demyelination Syndrome (ODS).

 

NDC-1308 (MC1)

LUNG INFLAMMATION

Chronic inflammation within the lungs can lead to respiratory distress and potential respiratory failure in response to viral infections such as SARS-CoV-2 and COVID-19.

NDC-1308 (MC2)

NEUROINFLAMMATION

Neuroinflammation is an immune system response to injury, infection, toxins, or autoimmunity in the Central Nervous System (CNS) and may result in neurodegeneration.

NDC-1308 (MC2)

NEURODEGENERATION

Neurodegeneration is the progressive loss of structure and / or function of neurons, including demyelination of the axons and death of neurons in the CNS.

ENDECE PIPELINE

ENDECE COVID-19 SARS-CoV-2
Niemann-Pick disease type C NPC1
Niemann-Pick disease type C NPC1
Neuromyelitis Optica Spectrum Disorder NMOSD
Multiple Sclerosis
Alzheimer's Disease
Osmotic Demyelination Syndrome

SARS-CoV-2 / COVID-19

NDC-1308 (MC1) reduces respiratory distress

  • Lung inflammation
  • Administration:

Inhalation / nebulizor directly to the lungs

  • discovery | preclinical | IND enabeling
  • SARS-CoV-2 is a virus that leads to COVID-19 and is easily spread, overwhelming the health care system and causing worldwide economic distress. NDC-1308 (MC1) reduces the risk of inflammation in lung tissue by upregulating key genes within macrophages to polarize them from the M1 (pro-inflammatory, anti-repair) state, to the M2 (anti-inflamatory, pro-repair) state, creating the right environment for reducing inflammation.

Niemann-Pick disease type C (NPC1)

  • Neuroinflamation / Neurodegeneration
  • Administration:
  • Intranasal delivery via nebulizor through the olfactory epithelium to the CNS

*RARE DISEASE

  • discovery | preclinical
  • Niemann-Pick disease type C (NPC1) is a rare genetic disorder in which gene mutations are passed from parents to children in a pattern called autosomal recessive inheritance, leading to progressive and lethal neurodegeneration.

Neuromyelitis Optica Spectrum Disorder (NMOSD)

  • Neuroinflamation / Neurodegeneration
  • Administration:
  • Intranasal delivery via nebulizor through the olfactory epithelium to the CNS

*RARE DISEASE

  • discovery | preclinical
  • Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune disease of the Central Nervous System (CNS) in which the immune system attacks the optic nerve and spinal cord. NMOSD is identified by the presence of antibodies to aquaporin-4 (AQP4), which distinguishes it from MS.

Multiple Sclerosis - Optic Neuritis

  • Neuroinflamation / Neurodegeneration
  • Administration:
  • Intranasal delivery via nebulizor through the olfactory epithelium to the CNS

  • discovery | preclinical
  • Multiple Sclerosis (MS) is an unpredictable, debilitating disease of the Central Nervous System (CNS). Nearly ONE MILLION people are living with MS in the United States, more than twice the original estimates.

Alzheimer’s Disease

  • Neuroinflamation / Neurodegeneration
  • Administration:
  • Intranasal delivery via nebulizor through the olfactory epithelium to the CNS

  • discovery
  • Alzheimer’s Disease has been an irreversible and progressive brain disorder that reduces memory, cognition, and one’s ability to execute the simplest tasks. Symptoms usually appear when a patient is in mid 60’s.

Osmotic Demyelination Syndrome (ODS)

  • Neuroinflamation / Neurodegeneration
  • Administration:
  • Intranasal delivery via nebulizor through the olfactory epithelium to the CNS

  • discovery | preclinical
  • Osmotic Demyelination Syndrome (ODS), also called Central Pontine Myelinolysis (CPM) and Extra Pontine Myelinolysis (EPM), is a demyelination within the pons region of the Central Nervous System (CNS) that interrupts the flow of information between the brain and body.