Developing NDC-1308 For Inducing Remyelination
How the Body Makes Myelin
the body’s natural process for forming mature, myelinating oligodendrocytes leading to myelin sheaths. The process start from oligodendrocyte progenitor cells (OPCs) that are located throughout the central nervous system (CNS).
NDC-1308 Induces the Body’s Natural System for Oligodendrogenisis
Step 1:Oligodendrocyte progenitor cells (OPCs) are present but quiescent
NDC-1308Designed to up-regulate key genes to induce remyelination
Step 2:Gene activated by NDC-1308
Step 3:Pre-oligodendrocytes become pre-myelinating oligodendrocytes
Step 4:Pre-myelinating oligodendrocytes become myelinating oligodendrocytes
DUAL MECHANISM OF ACTION
ENDECE is preparing to take NDC-1308 into clinical studies. Our scientists describe the dual mechanism of action that allows NDC-1308 to induce remyelination for treating diseases such as neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS), and Alzheimer’s disease.
- up-regulates lipoprotein lipase (LPL) expression causing a polarization in macrophages from the pro-inflammatory M1 like state to the anti-inflammatory, pro-repair state (M2-like phenotype); and
- turns on key genes within oligodendrocyte progenitor cells (OPCs) necessary for inducing OPCs to differentiate into mature oligodendrocytes which restore and maintain myelin sheaths.