Understanding Osmotic Demyelination Syndrome
Osmotic demyelination syndrome (ODS), also called central pontine myelinolysis (CPM) and extra-pontine myelinolysis (EPM), is a demyelination of the pons region of the central nervous system that interrupts the flow of information within the brain and body.
Demyelination:Destruction of myelin, the insulating layer around axons, essential for the proper functioning of the nervous system.
ODS is most often derived as a complication of treatment of patients with hypontremia (low serum sodium).
Correcting for hyponatremia too rapidly in the hospital can lead to:
Acute damage of the myelin sheath in the pons area of the brain
Patient care is primarily supportive only
Serious long-term (chronic) disability and potentially death
There is no cure or specific treatment currently available
Clinical Signs and Symptoms
ODS is first diagnosed clinically and confirmed by MRI. However, it often takes days to several weeks after acute symptoms occur for confirmation of demyelination of the pons to be detected by MRI.
Difficulty swallowing and / or speaking
Confusion, delirium, hallucinations
Balance problems, tremors
Reduced alertness, drowsiness, poor responses
There is no cure or specific treatment for ODS / CPM / EPM
Patients who develop ODS / CPM / EPM require long-term supportive care
There is no known cure or specific treatment
ENDECE is developing new drugs for diseases with limited or nonexistent treatment options
A new drug with the potential to induce remyelination in demyelinating diseases including
ODS / CPM / EPM and Multiple Sclerosis