ABOUT DEMYELINATING DISEASES


Conditions that result in damage to the myelin sheath in the central nervous system (CNS).

DEMYELINATING DISEASES

Demyelination may occur in one or a combination of specific areas in the CNS.

Demyelinating Diseases

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NEUROMYELITIS OPTICA SPECTRUM DISORDER:

(Optic Nerve and Spinal Cord)

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MULTIPLE SCLEROSIS (MS):

(Brain and Spinal Cord)

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OPTIC NEURITIS:

(Optic Nerve)

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OSMOTIC DEMYELINATION SYNDROME:

(Pontine Area of the Brain)

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ACUTE DISSEMINATED ENCEPHALOMYELITIS:

(Brain and Spinal Cord)

Symptoms

Symptoms vary greatly from disease to disease and person to person and may result in;


Physical and or cognitive impairment


Chronic progressive disability over years


One time event which may improve over time

Causes

Some types of demyelinating disorders occur when your immune system attacks your own tissues. But in many cases, doctors still aren’t certain what causes these conditions.



Current Therapies

current therapiesCurrent Treatments Focus On;

  • Minimizing the effects of the attacks
  • Slowing the course of the disease
  • Managing symptoms

To date there are no approved therapies for repairing or restoring myelin.

ENDECE Approach To Remyelination

ENDECE has discovered and is developing NDC-1308, a new therapy with a dual mechanism of action (MOA) designed to provide the necessary anti-inflammatory, pro-repair environment at lesions and upregulate genes necessary for inducing OPCs to differentiate into mature oligodendrocytes responsible for remyelination.

For more information see Developing NDC-1308





NDC-1308

A new drug with a unique dual mechanism of action (MOA) for inducing remyelination, the process for restoring and repairing the myelin sheath in demyelinating diseases including multiple sclerosis, neuromyelitis optica, and osmotic demyelination syndrome.   To learn more go to Developing NDC-1308.


To request more information go to; ENDECE.com/contact